Sari, Novieta Maya Primary Author mixed material bibliography Surabaya Fakultas Farmasi UNAIR 2009 monographic id Indonesia

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xiii; 65p.; 30cm To develop the new drug of analgesic-antipyretics group in this research, preparation of N-(4-hydroxyphenyl)benzamide had been done by reaction of p¬aminophenol and benzoyl chloride. The N-(4-hydroxyphenyl) benzamide prepared by solvent-modified Schotten-Baumann method was 51,00% and its melting point was 200-202°C. The compound was identified using the spectrophotometric data of ultraviolet and infrared, and nuclear magnetic resonance spectroscopic. The analgesic activity was tested using writhing test method. The result showed that in dose 25 mg/kg mice body-weight, the pain-inhibition percentage of N-(4-hydroxyphenyl) benzamide was 17,6%, in dose 50 mg/kg mice body-weight was 34,3% and in dose 100 mg/kg mice body weight was 54,1%. However, the standard compound paracetamol in dose 25 mg/kg mice body-weight, the pain-inhibition percentage was 15,3%, in dose 50 mg/kg mice body-weight was 32,0%, and in dose 100 mg/kg mice body-weight was 52,3%. Based on datas of pain-inhibition percentage concluded that N-(4-hydroxyphenyl)benzamide had analgesic activity and was higher than paracetamol. SALICYLIC ACID ANALGESICS 6B.S Sar s PERPUSTAKAAN FAKULTAS FARMASI - UNIVERSITAS HANG TUAH Jl. Arief Rachman Hakim 150 , Surabaya 60111 Telp: (031) 5945864, 5945894 Fax : (031) 5946261 , Web. www.hangtuah.ac.id 6B.S Sar s FARM87-6B.S-2015 Perpus Farmasi (Rak Skripsi) 6B.S Sar s skripsi_novieta_maya_sari.jpg.jpg 385 2015-10-19 08:01:30 2015-10-19 08:03:24 machine generated